Logo genzia Regionale di sanità ToscanaAgenzia Regionale Sanità

pubblicazioni scientifiche ARS Toscana 2015Autori: Barchielli A, Profili F, Balzi D, Francesconi P, Zuppiroli A, Cipriani F

Rivista: Epidemiol Prev. 2015;39(3):167-75

OBJECTIVE: To describe trends in attack rate, treatment, and outcomes of acute myocardial infarction (AMI) in Tuscany Region (Central Italy).

DESIGN: Population-based epidemiological study using the Tuscany Acute Myocardial Infarction Registry.

pubblicazioni ars 2015Autori: Coloma PM, de Ridder M, Bezemer I, Herings RM, Gini R, Pecchioli S, Scotti L, Rijnbeek P, Mosseveld M, van der Lei J, Trifirò G, Sturkenboom M; EU-ADR Consortium.

Rivista:  Osteoporos Int. 2015 Dec 22

Abstract
Analyses of healthcare data from 30 million individuals in three countries showed that current use of bisphosphonates may be associated with a small increased risk of cardiac valvulopathy (vs. those not exposed within the previous year), although confounding cannot be entirely ruled out. The observed tendency for decreased valvulopathy risk with cumulative duration of bisphosphonate use >6 months may even indicate a protective effect with prolonged use. Further studies are still needed to evaluate whether bisphosphonates increase or decrease the risk of valvulopathy.

pubblicazioni ars 2015Autori: Pacurariu AC, Straus SM, Trifirò G, Schuemie MJ, Gini R, Herings R, Mazzaglia G, Picelli G, Scotti L, Pedersen L, Arlett P, van der Lei J, Sturkenboom MC, Coloma PM.

Rivista:  Drug Saf. 2015 Dec;38(12):1201-10

BACKGROUND AND OBJECTIVE: Spontaneous reporting systems (SRSs) remain the cornerstone of post-marketing drug safety surveillance despite their well-known limitations. Judicious use of other available data sources is essential to enable better detection, strengthening and validation of signals. In this study, we investigated the potential of electronic healthcare records (EHRs) to be used alongside an SRS as an independent system, with the aim of improving signal detection.

pubblicazioni scientifiche ARS Toscana 2015Autori: Seghieri G, Policardo L, Profili F, Francesconi P, Anichini R, Del Prato S.

Rivista: J Diabetes Complications. 2015 Dec 11.

AIMS: To identify incidental previously unrecognized diabetes (IPUD) among hospitalized patients and corresponding mortality risk in comparison with individuals with known diabetes (KDM).