11/9/2013
Autori: Nuvolone D, Balzi D, Pepe P, Chini M, Scala D, Giovannini F, Cipriani F, Barchielli A
Rivista: Environ Res. 2013 Sep 5.




Abstract
OBJECTIVE:
Many studies have investigated the potential role of ozone exposure in cardiovascular mortality and morbidity. The effects on specific cardiovascular outcome and the role of individual susceptibility are less studied. This paper focuses on the short-term effects of ozone on acute coronary events and it investigates comorbidities as indicators of personal susceptibility.

SETTING AND PATIENTS:
This study was conducted in five urban areas of the Tuscany region (Italy) covering the period January 2002-December 2005. Air quality and meteorological data from urban background monitoring sites were collected. Hospital admissions for acute myocardial infarction and out-of-hospital coronary deaths were extracted from administrative database.

DESIGN:
Both time series and case-crossover designs were applied. The confounding effects of some time-dependent variables, such as temperature, were taken into account. Some potential susceptibility factors were investigated. Pooled estimates were derived from random-effect meta-analysis...

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